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It has been an incredible month for new research about MPNs and MPN-AP/BP! Here are some articles that caught my eye (by no means a comprehensive list!) #mpnsm #leusm
A large-scale GWAS identifying 17 MPN risk loci and suggesting MPN risk is associ w/ function & self-renewal of hematopoietic stem cells
https://www.nature.com/articles/s41586-020-2786-7">https://www.nature.com/articles/...
https://www.nature.com/articles/s41586-020-2786-7">https://www.nature.com/articles/...
Pre-clinical work in a murine MPN model demonstrating the potentiation of interferon-alpha with arsenic trioxide
https://rupress.org/jem/article/218/2/e20201268/211476/JAK2V617F-myeloproliferative-neoplasm-eradication">https://rupress.org/jem/artic...
https://rupress.org/jem/article/218/2/e20201268/211476/JAK2V617F-myeloproliferative-neoplasm-eradication">https://rupress.org/jem/artic...
Analysis of PV and ET patients identifying pathogenic mutations associated w/ early, intermediate, and late patterns of progression to AML
https://ashpublications.org/bloodadvances/article/4/19/4887/464197/Leukemic-evolution-of-polycythemia-vera-and">https://ashpublications.org/bloodadva...
https://ashpublications.org/bloodadvances/article/4/19/4887/464197/Leukemic-evolution-of-polycythemia-vera-and">https://ashpublications.org/bloodadva...
Retrospective analysis of MPN-BP patients undergoing transplant compared to de-novo AML and AML arising from MDS
https://ashpublications.org/bloodadvances/article/4/19/4748/463999/Comparison-of-outcomes-of-HCT-in-blast-phase-of">https://ashpublications.org/bloodadva...
https://ashpublications.org/bloodadvances/article/4/19/4748/463999/Comparison-of-outcomes-of-HCT-in-blast-phase-of">https://ashpublications.org/bloodadva...
And results from a Phase II study of Rux + decitabine in MPN-AP/BP patients
https://ashpublications.org/bloodadvances/article/4/20/5246/469734/Phase-2-study-of-ruxolitinib-and-decitabine-in#.X5eDhhmpZK4.twitter">https://ashpublications.org/bloodadva...
https://ashpublications.org/bloodadvances/article/4/20/5246/469734/Phase-2-study-of-ruxolitinib-and-decitabine-in#.X5eDhhmpZK4.twitter">https://ashpublications.org/bloodadva...
