Thread by @hswapnil, Next up The Ri-Cyclo trialVitamin R vs old and trusted cyclophosphamide in [...]

Swapnil Hiremath, MD, MPH

hswapnil

Next up

The Ri-Cyclo trial

Vitamin R vs old and trusted cyclophosphamide in membranous

Who will win?

#KidneyWk #LBCT ePoster 17

RI-CYCLO eligibility:
GFR > 30
Proteinuria > 3.5 g/day

#LBCT eposters at #KidneyWk

Intervention was Rituximab vs Cyclophosphamide/Pred (modified Ponticelli)

outcomes below
RI-CYCLo at #KidneyWk #LBCT eposters

Knowing @pietro_ravani is involved, not surprised to see a great CONSORT figure

RICYCLO at #KidneyWk LBCT posters

So what ahppened?

perhaps a wee bit faster remission in Cyclophosphamide - but overall no major difference

RICYLO at #kidneyWk LBCT posters

How about
proteinuria
creatinine
PLA2R

Nothing starkly different

RI-CYCLO at #KidneyWk #LBCT posters

Adverse events

As expected more leukopenia and pneumonia with Cyclo
More infusion reactions with Ritux

RI-CYCLO at #KidneyWk #LBCT

The authors pragmatic and sensible conclusions

Thanks @pietro_ravani and team!

#KidneyWk #LBCT RI-CYLO

as a throwback - the #NephJC MENTOR discussion where there were a few of us defenders for team cyclophosphamide @VelezNephHepato @NephrosisMo

http://www.nephjc.com/news/mentor

https://www.nephjc.com/news/ment... href="https://www.twtext.com//hashtag/KidneyWk"> #KidneyWk

MENTOR: Is Rituximab Ripened enough for Membranous? — NephJC

This week, we will discuss the MENTOR trial, which pitted rituximab versus cyclosporine for membranous nephropathy

http://www.nephjc.com/news/mentor

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