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Here is a comprehensive study on the Vaccine(s) that are being tested/studied for COVID-19. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094941/">https://www.ncbi.nlm.nih.gov/pmc/artic...
As SARS-CoV-2 enters human body through ACE-2 (Angotensin coverting enzyme 2) receptors, Angiotensin Blockers are viewed as potential therapy. @Dereklowe writes why it is incredibly complicated. https://blogs.sciencemag.org/pipeline/archives/2020/03/17/angiotensin-and-the-coronavirus">https://blogs.sciencemag.org/pipeline/...
Here is a RNAseq analysis of ACE-2 expression in different organs of human body. High ACE-2 expression in an organ (protein,which is not necessarily the same as RNA) means increased potential risks of Organ failure because of COVID-19.
Earlier today, found this ( https://www.biorxiv.org/content/10.1101/2020.03.28.013672v1)">https://www.biorxiv.org/content/1... pre-print from @JSheltzer that correlates smoking with increased ACE2 expression and thus increase risk from COVID-19. Similarly, diabetes, some anti-hypertension medicines are also known to drive ACE-2 expression.
Human ACE-2 Protein is 99% similar to Gorilla ACE-2 protein. This virus could potentially wipe out the Gorilla population(s). (P.S. I/we do not know about Gorilla immunity to the virus, neither have i done binding studies.)
If you are interested in how this virus (coronavirus) works in molecular level, like i am, here is a pretty good lecture https://youtu.be/8_bOhZd6ieM ">https://youtu.be/8_bOhZd6i...
The virus has multi-pronged molecular mechanism that works to evade interferon signaling (ie. Body recognizing virus is there) before it reaches its titer. This is what makes it dangerous.
The virus wasn& #39;t made in a lab, herr isa comprehensive study. https://www.sciencenews.org/article/coronavirus-covid-19-not-human-made-lab-genetic-analysis-nature">https://www.sciencenews.org/article/c...
