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Yes! Many of us have been working to shift the paradigm, to have an equitable evidence base and responsible use of biomedical interventions in pregnancy, including @pregnancyethics @riekevdgraaf @FrancoiseBaylis @fadenethx @annelyerly @anetrid + many many more. Some resources: https://twitter.com/first10em/status/1345131242048655360
Ethics guidance on fair, responsible and just inclusion of the interests of pregnant women and their offspring in epidemic vaccine research: http://vax.pregnancyethics.org
actionable #ethics guidance for advancing responsible HIV/co-infection research with pregnant women. http://www.hivpregnancyethics.org
“The second wave: Toward responsible inclusion of pregnant women in research” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2747530/
CIOMS international research ethics guidance - guideline 19
https://cioms.ch/wp-content/uploads/2017/01/WEB-CIOMS-EthicalGuidelines.pdf
https://cioms.ch/wp-content/uploads/2017/01/WEB-CIOMS-EthicalGuidelines.pdf
US Task Force on Research Specific to Pregnant Women and Lactating Women (PRGLAC) https://www.nichd.nih.gov/about/advisory/PRGLAC
“Protected to death: systematic exclusion of pregnant women from Ebola virus disease trials” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751665/
The ethics consensus is clear that we do a grave injustice to pregnant people & their offspring by excluding them wholesale from research - in many cases also threaten public health. Exclusion requires justification based on unfavorable risk-benefit and should never be default
We’ve been making progress but still a long way to go to ensure an appropriate and equitable evidence base to guide use of products in pregnancy and timely access to beneficial preventives and treatments in pregnancy
