Thread by @AliNouriPhD, #SARSCoV2 from transmissionto disease:1. Spike protein on the virus binds the ACE2 [...]

Dr. Ali Nouri

AliNouriPhD

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#SARSCoV2 from transmission

to disease

:

1. Spike protein on the virus binds the ACE2 receptor on human cells. The Virus RNA is released into the cell, where it is translated into proteins that assemble and make-up new virus particles that are then sent back out of the cell

#SARSCoV2 from transmissionto disease:1. Spike protein on the virus binds the ACE2 receptor on human cells. The Virus RNA is released into the cell, where it is translated into proteins that assemble and make-up new virus particles that are then sent back out of the cell

2. #SARSCoV2 comes out of the respiratory tract

on small aerosols that stay airborne and are then inhaled; on bigger respiratory droplets

that splash into others' nose/mouth/eyes or they land on surfaces and get picked up by touch; the virus is also excreted through human waste

2. #SARSCoV2 comes out of the respiratory tracton small aerosols that stay airborne and are then inhaled; on bigger respiratory dropletsthat splash into others' nose/mouth/eyes or they land on surfaces and get picked up by touch; the virus is also excreted through human waste

3. #COVID affects many of the body's systems—upper and lower respiratory tract

; heart

, where it can cause arrhythmias & other problems; digestive problems like nausea, pain, vomiting; neurological

problems where people suffer cognitive challenges even after recovery & more.

3. #COVID affects many of the body's systems—upper and lower respiratory tract ; heart, where it can cause arrhythmias & other problems; digestive problems like nausea, pain, vomiting; neurologicalproblems where people suffer cognitive challenges even after recovery & more.

4. When virus is inhaled & lodged deep into lungs it can cause a lot of damage. It gets inside airway cells & other cell types where it damages/kills them. It can also cause immune system cells (Macrophage/Neutrophils) to go haywire, further damaging lungs

respiratory failure.

4. When virus is inhaled & lodged deep into lungs it can cause a lot of damage. It gets inside airway cells & other cell types where it damages/kills them. It can also cause immune system cells (Macrophage/Neutrophils) to go haywire, further damaging lungsrespiratory failure.

5. There is so much we still don't know about #COVID19. Please take precaution, physical distance, wear a mask

, ventilate indoor spaces

, and practice good hygiene. https://www.cell.com/trends/immunology/fulltext/S1471-4906(20)30233-7?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1471490620302337%3Fshowall%3Dtrue

Mechanisms of SARS-CoV-2 Transmission and Pathogenesis

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) marks the third highly pathogenic coronavirus to spill over into the human population. SARS-CoV-2 is highly transmissible...

https://www.cell.com/trends/immunology/fulltext/S1471-4906(20)30233-7?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1471490620302337%3Fshowall%3Dtrue

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