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There is a “Benadryl challenge" on TikTok 
, so this seems like a good time to review Benadryl overdose 
H1 antagonist that can cross the
/
barrier
- delirium, psychosis, hallucination
- CNS depression
- Seizures
- Dystonic reactions
, so this seems like a good time to review Benadryl overdose H1 antagonist that can cross the
/ barrier- delirium, psychosis, hallucination
- CNS depression
- Seizures
- Dystonic reactions
Anti-cholinergic toxidrome:
- AMS
- Mydriasis
- Vasodilation/hyperemia
- Hyperthermia
- Anhydrosis/dry mucous membranes
- Urinary retention
- decreased GI motility
- AMS
- Mydriasis
- Vasodilation/hyperemia
- Hyperthermia
- Anhydrosis/dry mucous membranes
- Urinary retention
- decreased GI motility
Effects:- blocks inward-rectifier potassium channels (IKS)
delayed depolarization widened QRS and QTc-
risk arrhythmia- Tachycardia
- Get an EKG early
Pharmacokinetics:
- Peak serum levels at 2-3 hours
- Elimination half-life
7-12 hours
- Peak serum levels at 2-3 hours
- Elimination half-life
7-12 hours
Treatment:
- ABCs and supportive care
Seizures: Benzos
Arrhythmia: Bicarb
Antichoinergic: Physostigmine (if severe)
- Dialysis is NOT effective
- ABCs and supportive care
Seizures: BenzosArrhythmia: BicarbAntichoinergic: Physostigmine (if severe)- Dialysis is NOT effective
